ZETA|Newsroom|Rethinking Freeze & Thaw – Innovation at ZETA
From to ZETA
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Technical Text

Rethinking Freeze & Thaw – Innovation at ZETA

In biopharmaceutical manufacturing, Freeze & Thaw processes are critical for maintaining product integrity. ZETA has long been a pioneer in this field – and recent innovations from the ZETA TechCenter show just how far the technology has come.
ProductsResearch & DevelopmentSustainabilityTechnical Text
Person working with Freeze and Thaw System at ZETA

Water-free thawing and air-based freezing: A new generation of solutions

One of the most exciting developments is a water-free thawing bath that uses stainless steel beads as heat carriers instead of water. This approach enables gentle, uniform thawing across various packaging formats – from stainless steel containers to single-use bags. A pilot study confirmed the efficiency and consistency of heat transfer using a 700 ml model of a 300-liter industrial container.

In another forward-looking project, ZETA is testing a freeze system that uses air as the sole refrigerant – completely eliminating natural or synthetic gases. This innovation is designed to meet future EU regulations on refrigerant reduction while maintaining high performance. Initial trials have already been conducted, and a testable prototype is currently being validated through detailed temperature mapping.

From concept to GMP: Innovation with purpose

These developments are more than technical milestones – they reflect ZETA’s commitment to sustainable, scalable, and scientifically grounded process design. Whether it’s improving product safety, reducing environmental impact, or enabling modular production, ZETA continues to push the boundaries of what Freeze & Thaw can achieve.

Birgit Pittermann
Senior Manager Research & Development
Portrait picture of a person wearing a white shirt and a black blazer in front of a light background.
I would like to receive regular information and electronic advertising and agree that my data may be processed and used for this purpose by all companies of the ZETA Group worldwide.
zeta.com is committed to protecting and respecting your privacy, and we’ll only use your personal information to administer your account and to provide the products and services you requested from us. By submitting, I agree to the Terms of Use and the Privacy Policy.
>

Please complete the form to receive the requested content.

zeta.com is committed to protecting and respecting your privacy, and we’ll only use your personal information to administer your account and to provide the products and services you requested from us. By submitting, I agree to the Terms of Use and the Privacy Policy.

Show content