Design Study of Low Shear Agitators for Biopharmaceutical Applications

ZETA has conducted a comprehensive study to develop an optimal agitator configuration tailored to low shear systems. The result is a hydrofoil agitator as a reliable solution for large-scale biopharmaceutical production.

Research & DevelopmentTechnical Text

Hydrofoil Agitator: The Perfect Balance Between Efficiency and Cell Protection

The design of agitators for mammalian cell cultures must provide sufficient power input for effective mixing, heat transfer, oxygenation and CO2 stripping while minimizing shear forces to prevent cell damage.

This white paper, focusing on low-shear agitator configurations, builds on the white papers ‘Gassing Rate in Bioreactor Upscaling‘ and ‘Characterization of Bioreactors in Process-Based Upscaling,’ presenting new insights.

When designing the agitator, it is crucial to find a balance between providing sufficient energy for effective mixing, heat transfer, and oxygenation, while minimizing shear forces to prevent cell damage.

Get in touch Get in touch

Florian Krainer

Portfolio Manager

Portrait picture of a person wearing a white shirt and a black blazer in front of a light background.

First name*

Last name*

E-Mail address*

Company*

Country*

Website

I would like to receive regular information and electronic advertising and agree that my data may be processed and used for this purpose by all companies of the ZETA Group worldwide.

zeta.com is committed to protecting and respecting your privacy, and we’ll only use your personal information to administer your account and to provide the products and services you requested from us. By submitting, I agree to the Terms of Use and the Privacy Policy.

Message*