Bioreactors & Fermentation Systems

For cell culture from laboratory to production scale (10L – 30,000L)

The design of bioreactors for cell cultures depends strongly on the physiological characteristics of the cells. ZETA experts’ knowledge and understanding of these processes enables us to develop customised reactor systems that produce the best possible yield, purity and quality of the cell product. The optimisation of the process and technical equipment guarantee the following characteristics:

• Long-term sterility and high level of automation
• Homogeneous distribution of nutrients and uniform cell growth
• Low-resistance mixing without damaging cells
• Homogeneous oxygen and CO₂ supply
• Stringent control of process parameters such as pH value, temperature and pressure, over long periods

The ZETA R&D department is working on a number of projects with academic partners to drive progress in perfusion and microcarrier technologies, which will result in improvements in the performance of our bioreactors.

For yeast and bacterial cultures from laboratory to production scale (10L – 30,000L)

Microbiological fermentations place very high demands on equipment and process control. The highly dynamic process of biomass production is characterised by large oyxgen demand and strong heat generation. Achieving the necessary oxygen transport rate and quality of mixing and cooling depends critically on the reactor geometry. To enable our customers to reach their goal of high yields of microbiological product with moderate process costs, ZETA offers the following solutions:

• Process-specific analysis of
  - optimal reactor geometry
  - suitable mixing systems, with adaptation of the agitator/rotor type and geometry

• Optimisation of technical parameters such as
  - Gassing efficiency of the mixer (v_tip)
  - Gas transfer performance (k_La)
  - Mixing characteristics (Re, mixing time)
  - Power input per volume (P/V)

The reproducibility of the individual fermentation processes is guaranteed by customer-specific automation solutions, standardised CIP/SIP processes and defined control strategies.